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  • Sialyltransferase inhibition leads to inhibition of tumor cell . . .
    In this study, we explore the in vitro and in vivo effects of global sialyltransferase inhibition on myeloma cells using the pan-sialyltransferase inhibitor 3F ax -Neu5Ac delivered as a per-acetylated methyl ester pro-drug
  • Sialyltransferase inhibition leads to inhibition of tumor cell . . .
    Here we show that pre-treatment of MM cells enriched for E-selectin ligands with 3F ax -Neu5Ac, a global inhibitor of the ST family, 24 significantly reduces cell surface sialylation of these cells, prolongs survival in xenograft mice and enhances their in vivo sensitivity to bortezomib
  • Sialyltransferase inhibition leads to inhibition of tumor cell . . .
    Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model
  • Sialyltransferase inhibition leads to inhibition of tumor cell . . .
    In this study, we explore the in vitro and in vivo effects of global sialyltransferase inhibition on myeloma cells using the pan-sialyltransferase inhibitor 3Fax-Neu5Ac delivered as a per-acetylated methyl ester pro-drug
  • Sialyltransferase inhibition leads to inhibition of tumor cell . . .
    Specifically, we show in vivo that 3F (ax)-Neu5Ac improves survival by enhancing bortezomib sensitivity in an aggressive mouse model of MM However, 3F (ax)-Neu5Ac treatment of MM cells in vitro did not reverse bortezomib resistance conferred by bone marrow (BM) stromal cells
  • 73243910 - Haematologica
    Version 3 Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model
  • Publications – Macauley Lab
    Natoni A, Farrell ML, Harris S, Falanx C, Kirkham-Mccarthy, Macauley MS, Reagan MR, O’Dwyer M (2019) Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model





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