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  • Matrix metallopeptidase 13 - Wikipedia
    Collagenase 3 is an enzyme that in humans is encoded by the MMP13 gene [5][6] It is a member of the matrix metalloproteinase (MMP) family Like most MMPs, it is secreted as an inactive pro-form [7] MMP-13 has a predicted molecular weight around 54 kDa [8] It is activated once the pro-domain is cleaved, leaving an active enzyme composed of the catalytic domain and the hemopexin-like domain
  • Overview of MMP-13 as a Promising Target for the Treatment of . . .
    The results are consistent with a strong correlation between expressions of TGFβ1 and MMP-13 in OA-affected cartilage that TGF-β can upregulate the levels of MMP13 primarily through the SMAD independent pathway, suggesting TGF-β switches from a protective role observed from in vitro studies to a negative factor in OA-affected cartilage [69]
  • MMP13 Gene - GeneCards | MMP13 Protein | MMP13 Antibody
    MMP13 (Matrix Metallopeptidase 13) is a Protein Coding gene Diseases associated with MMP13 include Spondyloepimetaphyseal Dysplasia, Missouri Type and Metaphyseal Dysplasia, Spahr Type
  • Matrix Metalloproteinase-13 (MMP-13) Directly and Indirectly . . .
    C, generation of MMP-13-overexpressing cells pcDNA3 1-FLAG-MMP13 was transfected into HSC3 cells After selection, we obtained four stable clones and one stable pool clone of MMP-13-overexpressing cells
  • Entry - *600108 - MATRIX METALLOPROTEINASE 13; MMP13 - OMIM
    Absence of Mmp13 resulted in significant interstitial collagen accumulation due, in part, to lack of collagenase-mediated cleavage that normally occurs in growth plates and primary ossification centers Cartilaginous growth plate abnormalities persisted in adult mice and phenocopied defects observed in human hereditary chondrodysplasias
  • MMP13: The Key to Understanding Cartilage Degradation and . . .
    Explore MMP13, a crucial enzyme involved in cartilage degradation and bone remodeling Learn about its role in arthritis, osteoporosis, wound healing, and cancer, and discover the latest research and clinical trials on MMP13 inhibitors
  • Overview of MMP-13 as a Promising Target for the . . . - PubMed
    Osteoarthritis (OA) is a common degenerative disease characterized by the destruction of articular cartilage and chronic inflammation of surrounding tissues Matrix metalloproteinase-13 (MMP-13) is the primary MMP involved in cartilage degradation through its particular ability to cleave type II col …
  • Matrix metalloproteinase-13: A special focus on its . . .
    Bone remodeling is an orchestrated process involving osteoblasts and osteoclasts to maintain mineral homeostasis in the internal milieu, mediated chiefly by matrix metalloproteinases (MMPs) MMP13, one amongst the MMPs plays a premier role in bone remodeling, and mutations in MMP13 have been implicated in various pathologies including cancer and arthritis Transcriptional activation of MMP13





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