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  • NOTCH2NLC Gene - GeneCards
    NOTCH2NLC encodes a Notch homolog 2 N-terminal-like protein that enables Notch binding activity and participates in positive regulation of Notch signaling It is part of the NOTCH family and is localized to the extracellular region
  • NOTCH2NLC - Notch homolog 2 N-terminal-like protein C - Homo sapiens . . .
    Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed: 29561261, PubMed: 29856954, PubMed: 29856955)
  • NOTCH2NLC Repeat Expansion Testing | Neuronal Intranuclear Inclusion . . .
    Multiple Variantyx tests analyze the NOTCH2NLC repeat that causes multiple different neurological diseases when expanded NOTCH2NLC is just one of >40 expansion genes analyzed by Variantyx tests
  • NOTCH2NLC notch 2 N-terminal like C [Homo sapiens (human)] - Gene - NCBI
    Involved in cerebral cortex development and positive regulation of Notch signaling pathway Located in extracellular region Implicated in essential tremor 6; neuronal intranuclear inclusion disease; and oculopharyngodistal myopathy 3 [provided by Alliance of Genome Resources, Jul 2025]
  • NOTCH2NL - Wikipedia
    Proteins encoded by NOTCH2NL act as regulators of Notch signaling, a cell–cell communication mechanism that controls differentiation, proliferation, and cell death
  • Entry - *618025 - NOTCH2 N-TERMINAL-LIKE C; NOTCH2NLC - OMIM
    NOTCH2NLA, NOTCH2NLB, and NOTCH2NLC encode proteins containing the first 6 EGF repeats of NOTCH2, followed by a unique C-terminal domain NOTCH2NLA and NOTCH2NLC lack the NOTCH2 N-terminal secretory pathway signal peptide, whereas NOTCH2NLB retains the signal peptide
  • NOTCH2NLC notch 2 N-terminal like C - NIH Genetic Testing Registry (GTR . . .
    Go to complete Gene record for NOTCH2NLC Go to Variation Viewer for NOTCH2NLC variants Summary Predicted to enable calcium ion binding activity Involved in cerebral cortex development and positive regulation of Notch signaling pathway Located in extracellular region Implicated in essential tremor [provided by Alliance of Genome Resources
  • NOTCH2NLC gene information - The Human Protein Atlas
    NOTCH2NLC gene information - The Human Protein Atlas NOTCH2NLC () protein expression summary
  • Protein structure - NOTCH2NLC - The Human Protein Atlas
    Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project The RNA data was used to cluster genes according to their expression across single cell types
  • Orphanet: NOTCH2NLC-notch 2 N-terminal like C
    The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment Orphanet is part of the Gene Curation Coalition, a global effort to harmonise gene-level resources





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