alternation 音标拼音: ['ɔltɚn
, eʃən]
n . 交互,轮流,隔一个
交互,轮流,隔一个
alternation 交变; 交替
alternation 交变 交替
alternation n 1 :
successive change from one thing or state to another and back again ; "
a trill is a rapid alternation between the two notes "
Permutation \
Per `
mu *
ta "
tion \ (
p [~
e ]
r `
m [-
u ]"
t [=
a ]"
sn [
u ^]
n ),
n .
[
L .
permutatio :
cf .
F .
permutation .
See {
Permute }.]
1 .
The act of permuting ;
exchange of the thing for another ;
mutual transference ;
interchange .
[
1913 Webster ]
The violent convulsions and permutations that have been made in property . --
Burke .
[
1913 Webster ]
2 . (
Math .)
(
a )
The arrangement of any determinate number of things ,
as units ,
objects ,
letters ,
etc .,
in all possible orders ,
one after the other ; --
called also {
alternation }.
Cf . {
Combination },
n .,
4 .
(
b )
Any one of such possible arrangements .
[
1913 Webster ]
3 . (
Law )
Barter ;
exchange .
[
1913 Webster ]
{
Permutation lock },
a lock in which the parts can be transposed or shifted ,
so as to require different arrangements of the tumblers on different occasions of unlocking .
[
1913 Webster ]
Alternation \
Al `
ter *
na "
tion \,
n . [
L .
alternatio :
cf .
F .
alternation .]
1 .
The reciprocal succession of things in time or place ;
the act of following and being followed by turns ;
alternate succession ,
performance ,
or occurrence ;
as ,
the alternation of day and night ,
cold and heat ,
summer and winter ,
hope and fear .
[
1913 Webster ]
2 . (
Math .)
Permutation .
[
1913 Webster ]
3 .
The response of the congregation speaking alternately with the minister . --
Mason .
[
1913 Webster ]
{
Alternation of generation }.
See under {
Generation }.
[
1913 Webster ]
97 Moby Thesaurus words for "
alternation ":
Lissajous figure ,
back -
and -
forth ,
battledore and shuttlecock ,
beat ,
chain ,
coaction ,
coming and going ,
commutation ,
complementary distribution ,
concurrence ,
consecution ,
cooperation ,
counterchange ,
cross fire ,
cyclicalness ,
ebb and flow ,
engagement ,
exchange ,
fluctuation ,
flux and reflux ,
give -
and -
take ,
interaction ,
interchange ,
intercommunication ,
intercourse ,
interlacing ,
intermeshing ,
intermittence ,
intermittency ,
intermutation ,
interplay ,
intertwining ,
interweaving ,
interworking ,
lex talionis ,
measure for measure ,
mesh ,
meshing ,
meter ,
mutual admiration ,
mutual support ,
mutual transfer ,
mutuality ,
order ,
oscillation ,
pendulation ,
pendulum motion ,
periodicalness ,
periodicity ,
permutation ,
piston motion ,
progression ,
pulsation ,
quid pro quo ,
reappearance ,
reciprocality ,
reciprocation ,
reciprocity ,
recurrence ,
regular wave motion ,
reoccurrence ,
repetition ,
retaliation ,
return ,
reversion ,
rhythm ,
rhythmic play ,
rotation ,
row ,
seasonality ,
seesaw ,
seesawing ,
sequel ,
sequence ,
series ,
shifting ,
shuffling ,
sine wave ,
something for something ,
succession ,
teeter ,
teeter -
totter ,
teeter -
tottering ,
teetering ,
tit for tat ,
to -
and -
fro ,
tottering ,
train ,
transposal ,
transposition ,
undulation ,
ups and downs ,
vacillation ,
variation ,
vicissitude ,
wavering ,
wigwag
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Accurate Physics-Based Flexible Docking of Macrocyclic Ligands To address these limitations, we developed a new flexible macrocycle docking protocol based on existing Schrödinger technologies for macrocycle sampling and small molecule docking
Accurate physics-based flexible docking of macrocyclic ligands To address these limitations, we developed a new flexible macrocycle docking protocol based on existing Schrödinger technologies for macrocycle sampling and small molecule docking
Accurate Physics-Based Flexible Docking of Macrocyclic Ligands . . . In this study, we optimized our previous molecular dynamics-based sampling and docking pipeline specifically designed for the accurate prediction of macrocyclic compounds
Accurate physics-based flexible docking of macrocyclic ligands,ChemRxiv . . . To address these limitations, we developed a new flexible macrocycle docking protocol based on existing Schrödinger technologies for macrocycle sampling and small molecule docking
New MacroDock protocol for macrocycle docking: a preprint We outline a new approach for flexible docking of macrocyclic ligands and benchmarked this on a manually curated dataset of macrocycle-receptor complexes
Performance evaluation of flexible macrocycle docking in AutoDock Here, we characterize the performance of this improved flexible macrocycle leveraging the accelerated performance of AutoDock-GPU, using a large and diverse set of ligands from the PDB, spanning rings of multiple sizes, and including large and complex multicyclic molecules, such as vancomycin
Accurate Physics-Based Flexible Docking of Macrocyclic Ligands | Jacob . . . Excited to share that our paper describing a new approach for flexible docking of macrocyclic ligands has now been published!
SigmaDock: Untwisting Molecular Docking With Fragment-Based SE (3 . . . SigmaDock is the first deep learning approach to surpass classical physics-based docking under the PB train-test split, marking a significant leap forward in the reliability and feasibility of deep learning for molecular modelling
Docking with macrocycles — Autodock Vina 1. 2. 0 documentation Different approaches can be used to dock macrocyclic molecules, like identifying one or more low energy conformations and docking them as different ligands, but generating them and docking them separately can be a time-consuming task